Safety Information for Avapro (Irbesartan)
Because of the hydrochlorothiazide element, it is contraindicated in patients with anuria or hypersensitivity to sulfonamide-derived medicines
In patients with volume or sodium diminution (eg, patients strongly treated with diuretics or on dialysis), such diminution should be adjusted prior to administration of AVAPRO, or a minor initial dose of AVAPRO (75 mg) should be employed, to avoid possible symptomatic hypotension
Hypersensitivity reactions to hydrochlorothiazide may occur in patients with or without a history of allergy or bronchial asthma, but are more likely in patients with such a history
Thiazide diuretics have been reported to cause exacerbation or activation of systemic lupus erythematosus
Lithium generally should not be given with thiazides
Thiazides should be used with caution in patients with severe renal disease and in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma
Before taking AVAPRO (irbesartan) you should:
- Tell your doctor and pharmacist if you are allergic to AVAPRO (irbesartan) or any other drugs.
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements and products you are taking herbal products. Be sure to mention the following: diuretics, nifedipine (Adalat, Procardia) and tolbutamide (Orinase). Your doctor may change your dose or monitor you carefully for the development and complications associated with side effects.
- Tell your doctor if you should go on dialysis and if you have or have ever had heart failure or kidney disease.
- Tell your doctor if you plan to become pregnant or are breastfeeding.
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